Hallo,
interessante Studie: IGF-1 senkt den Insulinbedarf
http://diabetes.diabetesjourna…content/49/5/789.full.pdf
IGF-1 = Insulinähnliche Wachstumsfaktoren, wird in der Leber gebildet, wird auch von Bodybuildern gern genommen.
"These data increase our understanding of IGF-I action and
indicate possible mechanisms responsible for the action of
IGF-I on glucose and protein metabolism. The effects on
insulin-mediated glucose uptake are associated with reduced
NEFA levels, suggesting that enhanced insulin sensitivity
occurs via the glucose-NEFA cycle and, in turn, is related to
reductions in GH secretion. The effects of IGF-I on protein
metabolism are known to be complex and are thought to
involve intracellular phosphorylation of mitogen-activated
protein kinase and phosphatidylinositol 3-kinase, leading to
increases in protein synthesis (43). The leucine kinetic data
in this study provide evidence that, in addition to effects on
intracellular signaling, IGF-I may regulate amino acid transport
systems, thereby affecting delivery and utilization of
amino acids. Thus, IGF-I has a dual role in increasing insulin
action and sensitivity with respect to glucose and protein
metabolism, with an additional role on protein metabolism in
the basal non–insulin-stimulated state. Although further studies
are necessary to elucidate the molecular mechanisms of
IGF-I action, this in vivo study, which used a dose of IGF-I that
increased the mean IGF-I concentration to the upper limit of
the age-matched normal range, increases the understanding
of how IGF-I regulates protein and glucose metabolism in
type 1 diabetes"
Grüße
